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Molecular representation of the effect of halothane molecule 6 on the dynamics of the loop connecting helices M2 and M3 in the α-subunit. The helices of the subunit are color-coded: no halothane (red) and after binding of halothane 6 (16-ns snapshot) (cyan). The hydrophobic residues in the binding cavity are shown in green. The halothane 6 reduces the mobility of the loop and the aromatic residue Tyr-277.
