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. 2006 Feb;8(2):96–103. doi: 10.1593/neo.05583

Figure 2.

Figure 2

Effect of tumor cell-shed vesicles on endothelial cell motility and invasiveness. HUVEC motility (A and C) was tested in the Boyden chamber using isolated vesicles shed by human ovarian carcinoma cells CABA I (A; triangles) and A2780 (C; triangles) used as attractants. VEGF (10 ng/ml; squares) was used as a reference stimulus. In the invasion assay (B and D), HUVECs were stimulated by vesicles (5 µg) shed by CABA I (B) or A2780 (D), or by VEGF (10 ng/ml) used as a reference stimulus. Data (mean and SD of triplicates) represent the number of cells that migrated in 10 high-power fields (representative of two to four experiments). *P ≤ .05.