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. 2006 Feb;8(2):125–135. doi: 10.1593/neo.05556

Figure 7.

Figure 7

Treatment with GrB/scFvMEL sensitizes melanoma cells to ionizing radiation. Radiosensitization by GrB/scFvMEL was based on clonogenic cell survival assays. A375 (A), A375DR (B), and SKBR3-HP (C) cells were pretreated with GrB/scFvMEL (10 nM for 16 hours), the drug was washed off, and cells were irradiated at various doses and plated for clonogenic cell survival assay. Observed sensitizations were statistically significant at 2, 4, and 6 Gy dosage groups on A375 cells (P < .05) and at 4 and 6 Gy dosage groups on A375DR cells (P < .05 and .005, respectively). No statistically significant sensitization was observed in gp240 antigen-negative SKBR3 cells (P > 0.05).