Table 2.
Correlation between B7-H1 Expression in Tumor Cells and TIL and the Clinicopathological Parameters of 44 Breast Cancer Patients.*
| B7-H1 in Tumors | P† | B7-H1 in TIL | P | |||
| + | - | + | - | |||
| Age (years) | ||||||
| <40 | 5 (33)‡ | 10 (67) | .692 | 6 (40) | 9 (60) | .552 |
| ≥40 | 8 (28) | 21 (72) | 9 (31) | 20 (69) | ||
| Tumor size (cm) | ||||||
| <4 | 6 (25) | 18 (75) | .469 | 5 (21) | 19 (79) | .042 |
| ≥4 | 7 (35) | 13 (65) | 10 (50) | 10 (50) | ||
| Lymph node metastasis§ | ||||||
| Negative | 6 (40) | 9 (60) | .384 | 5 (33) | 10 (67) | .631 |
| 1–3 | 3 (30) | 7 (70) | 2 (20) | 8 (80) | ||
| 4–9 | 1 (9) | 10 (91) | 5 (45) | 6 (55) | ||
| ≥10 | 2 (29) | 5 (71) | 3 (43) | 4 (57) | ||
| Histologic grade (SBR) | ||||||
| II | 3 (13) | 20 (87) | .012 | 4 (17) | 19 (83) | .015 |
| III | 10 (48) | 11 (52) | 11 (52) | 10 (48) | ||
| Her2/neu status | ||||||
| Positive | 7 (44) | 9 (56) | .119 | 9 (56) | 7 (44) | .019 |
| Negative | 6 (21) | 22 (79) | 6 (21) | 22 (79) | ||
| Estrogen receptor status | ||||||
| Positive | 7 (21) | 26 (79) | .036 | 10 (30) | 23 (70) | .356 |
| Negative | 6 (55) | 5 (46) | 5 (45) | 6 (55) | ||
| Progesterone receptor status | ||||||
| Positive | 4 (17) | 20 (83) | .040 | 7 (29) | 17 (71) | .450 |
| Negative | 9 (45) | 11 (55) | 8 (40) | 12 (60) | ||
| Neoadjuvant chemotherapy | ||||||
| Without | 5 (26) | 14 (74) | .682 | 6 (32) | 13 (68) | .759 |
| With | 8 (32) | 17 (68) | 9 (36) | 16 (64) | ||
| Lymphocyte infiltration | ||||||
| None | 0 (0) | 4 (100) | .280 | 0 (0) | 4 (100) | .001 |
| Focal | 5 (28) | 13 (72) | 2 (11) | 16 (89) | ||
| Moderate | 3 (25) | 9 (75) | 5 (42) | 7 (58) | ||
| Severe | 5 (50) | 5 (50) | 8 (80) | 2 (20) | ||
*
In interpreting data and correlating them with clinicopathological parameters, the 5% expression of cells was the cutoff point below which the number of patients was considered as negative and above which the number of patients was considered as positive.
†
P values in italics represent significant data.
‡
Numbers inside parentheses are percentages of patients.
§
One sample has unknown LN+ status.