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Treatment of UM-SCC-17B tumors with (-)-gossypol causes a significant decrease in the number of mitotic figures. (A) Graphic representation ofmitotic index in 20 high-power fields in control and (-)-gossypol-treated tumors (P ≤ .01). Error bars indicate standard deviation. Representative high-power fields from control (B) and 15-mg/kg (-)-gossypol (C)-treated UM-SCC-17B tumors, stained with hematoxylin and eosin. Arrows indicate mitotic figures.
