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. 1968 Oct;3(8):795–800.

Modification of the graft-versus-host syndrome by anti-lymphocyte serum treatment of the donor

J L Boak, R E Wilson
PMCID: PMC1578957  PMID: 5718503

Abstract

Spleen and lymph node suspensions prepared from parental donor mice pretreated with four daily anti-lymphocyte serum (ALS) injections have been demonstrated to be incapable of inducing a graft-versus-host (GVH) syndrome when injected into F1 hybrid recipient mice. A single ALS injection to the parental donor renders thoracic duct lymphocytes incapable of inducing a GVH response but the activity of spleen cell suspensions is retained.

It is suggested that this observation supports the view that ALS acts mainly on circulating lymphocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson N. F., James K., Woodruff M. F. Effect of antilymphocytic antibody and antibody fragments on skin-homograft survival and the blood-lymphocyte count in rats. Lancet. 1967 May 27;1(7500):1126–1128. doi: 10.1016/s0140-6736(67)91706-0. [DOI] [PubMed] [Google Scholar]
  2. BOAK J. L., WOODRUFF M. F. A MODIFIED TECHNIQUE FOR COLLECTING MOUSE THORACIC DUCT LYMPH. Nature. 1965 Jan 23;205:396–397. doi: 10.1038/205396a0. [DOI] [PubMed] [Google Scholar]
  3. Boak J. L., Dagher R. K., Corson J. M., Wilson R. E. Modification of the graft-versus-host syndrome by anti-lymphocyte serum treatment of the host. Clin Exp Immunol. 1968 Oct;3(8):801–808. [PMC free article] [PubMed] [Google Scholar]
  4. Boak J. L., Fox M., Wilson R. E. Activity of lymphoid tissues from antilymphocyte-serum-treated mice. Lancet. 1967 Apr 8;1(7493):750–752. doi: 10.1016/s0140-6736(67)91366-9. [DOI] [PubMed] [Google Scholar]
  5. Denman A. M., Denman E. J., Holborow E. J. Suppression of Coombs-positive haemolytic anaemia in NZB mice by antilymphocyte globulin. Lancet. 1967 May 20;1(7499):1084–1086. doi: 10.1016/s0140-6736(67)92653-0. [DOI] [PubMed] [Google Scholar]
  6. Gray J. G., Monaco A. P., Wood M. L., Russell P. S. Studies on heterologous anti-lymphocyte serum in mice. I. In vitro and in vivo properties. J Immunol. 1966 Feb;96(2):217–228. [PubMed] [Google Scholar]
  7. Guttmann R. D., Carpenter C. B., Lindquist R. R., Merrill J. P. An immunosupressive site of action of heterologous antilymphocyte serum. Lancet. 1967 Feb 4;1(7484):248–249. doi: 10.1016/s0140-6736(67)91306-2. [DOI] [PubMed] [Google Scholar]
  8. James K. In vivo and in vitro effect of anti-lymphocytic IgG on sensitized spleen cells. Nature. 1968 Jan 20;217(5125):261–262. doi: 10.1038/217261a0. [DOI] [PubMed] [Google Scholar]
  9. Levey R. H., Medawar P. B. Further experiments on the action of antilymphocytic antiserum. Proc Natl Acad Sci U S A. 1967 Aug;58(2):470–477. doi: 10.1073/pnas.58.2.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Martin W. J., Miller J. F. Site of action of antilymphocyte globulin. Lancet. 1967 Dec 16;2(7529):1285–1287. doi: 10.1016/s0140-6736(67)90395-9. [DOI] [PubMed] [Google Scholar]
  11. SIMONSEN M. Graft versus host reactions. Their natural history, and applicability as tools of research. Prog Allergy. 1962;6:349–467. [PubMed] [Google Scholar]
  12. WOODRUFF M. F., ANDERSON N. A. EFFECT OF LYMPHOCYTE DEPLETION BY THORACIC DUCT FISTULA AND ADMINISTRATION OF ANTILYMPHOCYTIC SERUM ON THE SURVIVAL OF SKIN HOMOGRAFTS IN RATS. Nature. 1963 Nov 16;200:702–702. doi: 10.1038/200702a0. [DOI] [PubMed] [Google Scholar]
  13. WOODRUFF M. F., SYMES M. O. The use of immunologically competent cells in the treatment of cancer: experiments with a transplantable mouse tumour. Br J Cancer. 1962 Dec;16:707–715. doi: 10.1038/bjc.1962.82. [DOI] [PMC free article] [PubMed] [Google Scholar]

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