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Failure to induce tolerance when cells are transferred from IL-10−/− UV-irradiated donor mice. Lymph node cells were isolated from hapten-sensitized mice (FITC), UV-irradiated hapten-sensitized WT mice (UV + FITC), or UV-irradiated hapten-sensitized IL-10-deficient mice (UV + FITC IL-10−/−). CHS and tolerance were determined as described previously.*, A statistically significant difference (p < 0.0001) from the FITC+ WT control.
