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. 2000 Feb 18;97(5):2297–2302. doi: 10.1073/pnas.040562597

Figure 2.

Figure 2

Neurotrophin requirements in developing DRG. (a) TUNEL staining was examined at E11 in wt, BDNF, NT-4, and BDNF/NT-4 mutant mice. (b) Peripherin-immunostained cells in wt and mutant DRG. (c– e) Primary culture of wt, BDNF, NT-4, and BDNF/NT-4 mutant E13 DRG neurons incubated with 2 ng/ml BDNF (c), 2 ng/ml NT-4 (d), and 10 pg/ml NT-3 (e). (f) Primary DRG neurons cultured in the presence of NGF, BDNF, and NT-3. Small-soma-diameter neurons (arrowhead) are NGF-dependent, whereas large-soma-diameter neurons (arrow) are BDNF- or NT-3-dependent.