Table 1.

Sensory neuron counts in the dorsal root and trigeminal ganglia of wt and mutant mice

	DRG				Trigeminal
	E13	Reduction, %	P0	Reduction, %	P0	Reduction, %
wt	16,245  ± 651c		4,434  ± 124g		27,005  ± 640b
NT-4 −/−	15,689  ± 646c	NS	4,986  ± 236f	φ*	26,407  ± 1,059a	NS
BDNF −/−	11,274  ± 134c,h	31*	3,235  ± 177f	27***	21,418  ± 786a	21**
NT-4 and BDNF −/−	16,437  ± 915c	NS	4,311  ± 182c	NS	24,628  ± 1,142b	9*
NT-3 −/−	10,459  ± 265b,h	36**	960  ± 51d	78***	9,501  ± 1,287b	65***
NT-3 and NT-4 −/−	7,820  ± 407a,h	52***	412  ± 26c	91***	6,133  ± 271a	77***
NT-3 and BDNF −/−	8,789  ± 625c	46**	687  ± 63d	84***	6,932  ± 573c,h	74***
TrkA −/−	ND		706  ± 23b	84***	ND
TrkA and NT-4 −/−	ND		791  ± 55c	82***	ND

Neuron numbers (mean ± SEM) of dorsal root and trigeminal ganglia were counted in E13 and P0 mouse spinal cords and heads of wt, NTF/Trk receptor mutant mice. Tissues were fixed in Bouin's solution, embedded in paraffin, serially sectioned (5 μm), and stained with H&E. The tissue slides were counted every 40 μm at P0 and every 20 μm at embryonic stages. No correction was made for split nuclei. Mann–Whitney rank sum test determined the significance levels. φ, A significant increase of 12% (P < 0.05); NS, not significant; ND, not determined. *, P < 0.05; **, P < 0.01; ***, P < 0.001. 

^an = 2. 

^bn = 3. 

^cn = 4. 

^dn = 5. 

^en = 6. 

^fn = 9. 

^gn = 10. 

^hPreviously described in Liebl et al. (5).