Table 1.
Detailed distribution of sodium channel subunits in the adult rat brain
| Brain region | ROD
|
||
|---|---|---|---|
| αIIA | β1 | β3 | |
| Olfactory system | |||
| Anterior olfactory | +++ | 1/2 | +++ |
| Olfactory tubercle | +++ | 1/2 | +++ |
| Piriform cortex | ++++++ | ++ | ++++ |
| Neocortex | |||
| Layer 2 | +++ | + | +++ |
| Layer 3 | +++ | + | +++ |
| Layer 4/5 | ++ | +++ | 1/2 |
| Layer 6a/6b | +++ | 0 | + |
| Subiculum | ++ | 1/2 | ++ |
| Hippocampus | |||
| CA1 | ++++ | +++ | ++++++ |
| CA2 | ++++++ | +++ | ++++++ |
| CA3 | ++++++ | +++++ | ++++++ |
| Dentate gyrus | +++++ | +++ | ++++++ |
| Hilus dentate gyrus | ++ | + | ++ |
| Indusium gresium | ++++ | 0 | + |
| Tenia tecta | ++++ | + | ++++++ |
| Basal ganglia | |||
| Caudate putamen | + | 0 | +++ |
| Globus palidus | 0 | 0 | 0 |
| Nucleus accumbens | + | 0 | ++ |
| VBD | 1/2 | 0 | 1/2 |
| Habenula | ++++ | 0 | +++++ |
| Amygdala | + | 0 | ++ |
| Hypothalamus | 1/2 | 0 | 1/2 |
| Preoptic area | 1/2 | 0 | 1/2 |
| Supraoptic | + | 0 | 1/2 |
| Mammilary body | + | 0 | + |
| Substantia nigra | 1/2 | 0 | 1/2 |
| VTA | + | 0 | |
| Cerebellum | |||
| Granular cell layer | ++++++ | +++++ | 0 |
| Purkinje cell layer | +++ | +++++ | 0 |
| Molecular cell layer | 0 | 0 | 0 |
| Thalamus | |||
| Reticular nucleus | 0 | 1/2 | 0 |
| Medial geniculate nuclei | 1/2 | ++ | 0 |
| Ventrolateral geniculate | ++ | + | 1/2 |
| Dorsal lateral nuclei | 0 | + | 0 |
| Anteroventral/dorsal nuclei | ++ | ++ | 0 |
| Ventral nuclei | + | 1/2 | 0 |
| Venteropostero nuclei | 0 | + | 0 |
| Midbrain | |||
| Superior colliculus | 1/2 | 0 | 1/2 |
| APTD | ++ | 1/2 | 1/2 |
| DpMe | 1/2 | 0 | 0 |
| Oculomotor nucleus | + | 0 | 1/2 |
| Red nucleus | + | 1/2 | 0 |
| Interpeduncular nucleus | + | 0 | 0 |
| Inferior colliculus | 1/2 | 1/2 | |
| Central grey | 0 | 1/2 | |
| Brainstem | |||
| Pontine nucleus | 0 | +++ | 0 |
| Trapezoid body | + | ++ | 0 |
| Inferior olivary nucleus | 0 | + | 1/2 |
| Locus ceruleus | + | 0 | + |
| Raphe nuclei | 0 | 1/2 | 0 |
| Pontine reticular formation | 0 | 1/2 | 0 |
| Motor trigeminal nucleus | 1/2 | + | 0 |
| Me5 cells | + | 0 | 0 |
| Facial nuclei | 0 | 1/2 | 0 |
| Vestibular nuclei | 0 | 1/2 | 0 |
| Solitary nucleus | 0 | 1/2 | 0 |
| Cuneate nucleus | 0 | +++ | 0 |
| Dorsal tegmental nucleus | + | 1/2 | + |
| Lateral parabrachial nucleus | + | 0 | 0 |
| Hypoglosseal nucleus | 1/2 | 0 | 0 |
| Spinal trigeminal nucleus | 1/2 | 1/2 | 0 |
| Septum | |||
| Bed nucleus stria terminalis | + | 0 | + |
| Lateral septal nucleus | + | 0 | + |
In situ hybridization signal observed for 35S-labeled oligonucleotide probes to rat αIIA, β1, and β3 mRNA on adult rat brain sections (emulsion-dipped sections and autoradiographs) were rated for relative optical density (ROD): ++++++, +++++, very abundant; ++++, abundant; +++, moderate; ++, +, low; 1/2, just above background; 0, not detectable (n = 3–6). VBD, nucleus of the vertical limb of the diagonal band; VTA, ventral tegmental area; APTD, anterior pretectal nucleus (dorsal part); DpMe, deep nucleus.