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. 2000 Feb 18;97(5):2326–2331. doi: 10.1073/pnas.030438797

Figure 2.

Figure 2

Mutation of the isoform-specific residue of μ1 IP-loop to heart sequence (μ1-Y401C) allows block by external QX222. (A and B) Typical current traces before (con) and 12 min after external application of 500 μM QX222 recorded from (A) μ1-WT and (B) μ1-Y401C. (C) Effects of externally applied 500 μM QX222 on μ1-WT (○) and μ1-Y401C (●). The bar indicates the period of exposure to 500 μM QX222 in the bath solution. Data represent the means ± SEM from eight oocytes for μ1-WT and nine for μ1-Y401C. Currents were elicited by 35-ms pulses to −10 mV from a holding potential of −100 mV at 20-s intervals (A–C), and peak currents were normalized to peak current in control and plotted as relative Na+ currents (relative INa) (C).