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Sequence alignment of human HNF1α and HNF1β. Identical residues and homologous residues are shown in red and blue, respectively. POUS and POUH regions are also highlighted by boxes with cyan and orange backgrounds, respectively. Within the DNA-binding domain region, sequence variations are minimal except the flexible linker between the two domains where insertion/deletion has occurred. The starting residue numbers are indicated in parentheses.
