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. 1999 Mar 16;96(6):2639–2644. doi: 10.1073/pnas.96.6.2639

Figure 2.

Figure 2

Alignment of h-SMRT and human N-CoR (hN-Cor). (A) The protein sequences were aligned by using the clustal alignment program. Identical residues are white with a black background. The arrow indicates the start of s-SMRT. (B) The diagram highlights the regions of homology between the SMRT N-terminal 1,031 aa and the corresponding N-CoR sequence (GenBank accession no. AF044209). The amino acids 1–160 are colored black to indicate this region as the Siah2 interacting domain. Amino acids 255–312 represent the Sin3A interaction domain mapped in N-CoR. Within the SANT region (amino acids 312–668), the actual SANT repeats are highlighted in black. The black-shaded region in the RD2 homology region represents the further defined repression core between amino acids 845 and 986. Percent similarities were calculated for each region by using the blastp program with a bosum62 matrix.