Figure 3.

Ebo-74 forms a trimer-of-hairpins structure. (A) A side view of the Ebo-74 structure. N helices (dark blue) constitute a central coiled coil and C helices (red) pack into hydrophobic grooves on the surface of the coiled coil. Disulfides within the loop regions (light blue) are depicted in yellow. (B) Each monomer has an α-helical hairpin conformation. The last three turns of the N helix, followed by the short α- and 3₁₀-helices (magenta), correspond to the immunosuppressive motif region in oncogenic retroviruses. Figure was generated by using insight ii (64).