Table 1.

Frequency of c-myc Amplification/Overexpression in Barrett Adenocarcinomas Based on Available Literature.

Publication	n	Method	Frequency of c-myc Amplification/Overexpression
Investigation of the amplification of the c-myc gene in the 8q23 chromosomal region
Miller et al. [8]	87	Southern blot analysis	4 of 87 (4.6%)
Sarbia et al. [7]	43	Differential PCR	17 of 39 (43.6%)
Arnould et al. [18]	15*	Comparative genomic hybridization (CGH)	Gain of 8q24 in 8 of 15 cases (53.3%)
Bhargava et al. [19]	28†	CGH	Gain of 8q in 79% recurrent high-level amplifications of 8q23-24.1 in > 10%
Walch et al. [6]	30	CGH	High-level amplification of 8q23-24 in 24 of 30 cases (80%)
Current investigation	84	CISH	70 of 84 (83.3%)
Investigation of c-myc protein overexpression
Tselepis et al. [9]	20	Western blot analysis	18 of 20 (90%)

^*Adenocarcinomas of the esophagus or gastroesophageal junction. No further information is given in the paper. Thus, this paper does not deal with pure Barrett cancer collective data.

^†Only 11 adenocarcinomas of the distal esophagus. The remaining 17 tumors under investigation were adenocarcinomas located at a lower level of the esophagogastric junction (not Barrett cancers).