Table 2.
Level of c-myc Amplification in the Whole Population (n = 84 Eligible Primary Resected Barrett Cancer Cases Investigated with CISH) and in Subgroups.
| n | No Amplification [n (%)] | Low-Level Amplification [n (%)] | High-Level Amplification [n (%)] | P (Chi-Square Analysis) | |
| Whole population | 84 | 14 (16.7) | 63 (75.0) | 7 (8.3) | |
| Subgroups Age (years) | |||||
| < 64 | 45 | 6 (13.3) | 34 (75.6) | 5 (11.1) | ns |
| > 64 | 39 | 8 (20.5) | 29 (74.4) | 2 (5.1) | |
| Sex | |||||
| Male | 78 | 14 (18.0) | 57 (73.1) | 7 (9.0) | ns |
| Female | 6 | 0 | 6 (100.0) | 0 | |
| Tumor size* (mm) | |||||
| < 50 | 52 | 7 (13.5) | 38 (75.0) | 6 (11.5) | ns |
| > 50 | 32 | 6 (18.8) | 25 (78.1) | 1 (3.1) | |
| Depth of invasion (pT category) | |||||
| pT1/2 | 47 | 8 (9.5) | 34 (40.5) | 5 (6.0) | ns |
| pT3/4 | 37 | 6 (7.1) | 29 (34.5) | 2 (2.4) | |
| Lymph node involvement (pN category) | |||||
| pN0 | 40 | 8 (20.0) | 28 (70.0) | 4 (10.0) | ns |
| pN1 | 44 | 6 (13.6) | 35 (79.6) | 3 (6.8) | |
| Lymphatic vessel invasion (L category) | |||||
| L0 | 59 | 11 (18.6) | 45 (76.3) | 3(5.1) | ns |
| L1 | 25 | 3 (12.0) | 18 (72.0) | 4 (16.0) | |
| UICC stage | |||||
| I/II | 55 | 9 (16.4) | 40 (72.7) | 6 (10.9) | ns |
| III/IV | 29 | 5 (17.2) | 23 (79.3) | 1 (3.5) | |
| Differentiation (grade) | |||||
| G1/2 | 41 | 6 (14.6) | 33 (80.5) | 2 (4.9) | ns |
| G3/4 | 43 | 8 (18.6) | 30 (69.8) | 5 (11.6) | |
| Lauren classification | |||||
| Diffuse | 2 | 0 | 1 (50.0) | 1 (50.0) | .0466 |
| Intestinal | 74 | 14 (18.9) | 56 (75.7) | 4 (5.4) | |
| Mixed | 8 | 0 | 6 (75.0) | 2 (25.0) | |
*
Size range: 5 to 130 mm.