. 2006 Sep 30;333(7570):675. doi: 10.1136/bmj.38905.634132.AE

Table 2.

Outcomes reported in trials

Outcome	Reporting
Distinct allergy related symptoms or combinations of symptoms
Haemodynamic	Hypotension^{w2 w4 w8}
Respiratory	Bronchospasm,^{w2 w3} laryngeal oedema,^w2 urticaria or angio-oedema (combined)^w6
Cutaneous	Erythema,^w6 facial or eyelid oedema,^w8 periorbital oedema,^w2 flush,^w6 flush or erythema,^w2 hives,^{w2 w8 w9} pruritus,^{w2 w8} hives or pruritus,^w7 urticaria^{w3 w9}
Arbitrary symptom combinations (grades)
Grade 1	Single episode of emesis, nausea, sneezing, or vertigo^{w1 w2}
Grade 2	Hives, erythema, emesis more than once, and fever or chills (or both)^{w1 w2}
Grade 3	Clinical “shock,” bronchospasm, laryngospasm or oedema, loss of consciousness, convulsions, fall in blood pressure, increase in blood pressure, cardiac arrhythmia, angina, angio-oedema, or pulmonary oedema^{w1 w2}
Non-specific symptoms or symptom combinations
Any non-specific symptoms	Any reaction, ^{w1-w5 w7-w9} other objective or subjective symptoms,^w6 treatment needed^w1
Non-specific respiratory symptoms	Dyspnoea,^w2 respiratory symptoms,^w6 cough,^w9 tachypnoea^w9
Non-specific cardiovascular symptoms	Hypertension,^w2 change in blood pressure,^w9 palpitations,^w2 tachycardia,^w9 heat sensation^{w6 w9}
Emetic symptoms	Nausea,^{w2-w6 w8 w9} vomiting,^{w2 w3 w5 w8 w9} nausea or vomiting^{w7 w8}
Other symptoms	Sneezing,^{w2 w9} chest pain,^{w8 w9} chills,^w8 chills or fever,^w2 headache,^{w5 w9} vertigo,^{w2 w4 w5 w9} tinnitus^w5
Adverse drug reactions
Dexamethasone, methylprednisolone	Reaction to premedication (bitter taste, nausea, headache),^w2 insomnia,^w5 dyspepsia,^w5 spinal pain^w5
Hydroxycine, clemastine	Somnolence,^w3 anticholinergic reaction,^w3 bad taste,^w9 local skin reaction^w9