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. 2006 Oct 3;3(10):e420. doi: 10.1371/journal.pmed.0030420

Figure 3. Dysfunctional KEAP1–NRF2 Interaction in NSCLC Tumors.

Figure 3

(A) Immunohistochemical analysis of NRF2 in NSCLC tissues. Part a shows a patient (PT-18) with mutation in KEAP1 showing strong nuclear and cytoplasmic staining. Part b shows a patient negative for mutation (PT-28) showing weak cytoplasmic staining. Part c shows a patient negative for mutation (PT-20) showing increased nuclear and cytoplasmic staining in tumor tissue. Part d shows weakly staining normal bronchus from the same patient (PT-20).

(B) Total GSH and enzyme activities of NQO1 and total GST in NSCLC and matched normal tissues. Raw data for the heat maps are presented in Table S4. *, samples harboring KEAP1 mutation; §, nmol/mg protein; †, nmol DCPIP reduced/min/mg protein; ‡, nmol of product formed/min/mg protein.