Table 1.

Summary of in vivo injection experiments

Solution injected	Average number of centrosomes*		Ratio, I/U†
	Injected cells	Uninjected cells
Control‡	6.4 ± 0.8	7.3 ± 0.6	0.88
	n = 18	n = 31
p21, 3 μM	1.9 ± 0.3	6.0 ± 0.6	0.32§
	n = 20	n = 20
p21, 2 μM	2.1 ± 0.2	10.4 ± 0.6	0.20§
	n = 36	n = 38
p21, 1.5 μM	2.5 ± 0.2	5.5 ± 0.4	0.45§
	n = 32	n = 23
p21, 1 μM	3.1 ± 0.3	5.6 ± 0.5	0.55§
	n = 52	n = 51
p21 + cyclin E‖	7.7 ± 0.5	7.5 ± 0.5	1.03
	n = 40	n = 34
p21 N terminus, 10 μM	0.9 ± 0.3	5.8 ± 0.4	0.16§
	n = 11	n = 15
p21 N terminus, 5 μM	1.2 ± 0.2	7.6 ± 0.8	0.16§
	n = 29	n = 19
p21 C terminus, 8 μM	5.9 ± 0.3	5.4 ± 0.3	1.09
	n = 33	n = 36
p27 N terminus, 16 μM	0.9 ± 0.2	5.8 ± 0.7	0.16§
	n = 35	n = 29
p27 N terminus, 8 μM	2.8 ± 0.2	7.5 ± 0.5	0.37§
	n = 30	n = 30
p27 C terminus, 10 μM	4.6 ± 0.3	5.3 ± 0.4	0.87
	n = 40	n = 40
p27 C terminus, 5 μM	6.9 ± 0.5	6.9 ± 0.5	1.00
	n = 29	n = 30

n is the number of cells counted for each condition. 

^*The average number of centrosomes is shown ±SEM. 

^†The ratio is centrosome number for injected cells divided by centrosome number for uninjected cells. 

^‡The control solution used was PBS. 

^§For these experiments, the average number of centrosomes in injected cells vs. uninjected cells is significantly different within a 99% confidence level. 

^‖Cyclin E was added at twice the molarity of p21.