Table 2.
SNPs identified in AKR1C genes genotyped in 1/4 Meishan F8 and F10 population.
| Allele frequencies3 | ||||||||
| Assay | Gene | Accession1 | Location2 | Polymorphism | F8 & F10 | MS | WC | Polymorphic site4 |
| 33391_261 C/T | AKR1CL2 | BV102614 | Intron 1 | T = 0.63 | T = 0.21 | T = 0.81 | ccctgcacagYagcgcgggca | |
| 49422_42 A/T | AKR1C2 | BV680531 | nt 179 | Ile16Phe | A = 0.77 | A = 0.50 | A = 1.00 | cggtcacctcWttcctgtact |
| 36962_196 A/T | AKR1C2 | DQ474066 | nt 779 | Tyr216Asn | A = 0.62 | A = 0.17 | A = 0.89 | tttggttgccWatgctgccct |
| 36962_681 A/G | AKR1C2 | DQ474066 | nt 833 | Val234 Ile | G = 0.85 | ND | ND | aaaccacccaRttctcttgg |
| 31063_1495 G/T | AKR1C4 | BV680526 | promoter | ERE site | T = 0.55 | T = 0.10 | T = 0.94 | tcagagtactKaccttgacca |
| 31503_2415 A/G | AKR1C4 | BV680525 | Exon 1 | silent | G = 0.81 | G = 1.00 | G = 0.67 | tgagtagtggRgaagagacgt |
| 27648_208 C/T | AKR1C4 | BV680527 | Exon 1 | silent | T = 0.67 | T = 0.36 | T = 0.86 | agctgaatgaYgggcacctca |
| 20502_681 C/T | AKR1C4 | BV680537 | Intron 2 | C = 0.57 | C = 0.17 | C = 0.92 | cttttagctaYtgatgtttmc | |
| 20502_722 C/T | AKR1C4 | BV680537 | Intron 2 | C = 0.78 | C = 0.50 | C = 1.00 | aaatcayaagYcatttttaat | |
| 14984_99 G/T | AKR1C4 | BV680523 | Intron 4 | T = 0.56 | ND | ND | aaatgtgggtKtgatccctgg | |
| 36969_772 C/T | AKR1C4 | BV680543 | Exon 7 | silent | C = 0.56 | C = 0.25 | C = 0.94 | agaaacacaaYagaagcccag |
| 49431_198 C/T | AKR1C4 | BV680533 | Intron 8 | Splice site | T = 0.58 | T = 0.50 | T = 0.81 | ttcccttcctYycaggtttttr |
1Accession numbers beginning with BV are sequences submitted to dbSTS.
2Location refers to nucleotide position in cDNA.
3Allele frequencies were calculated from F8 and F10 animals genotyped (ranging from 238–420 animals), and founder Meishan (MS) and founder White composite (WC) animals (7–10 animals each) in the original resource population; ND = not determined.
4Polymorphisms are identified by IUB code with flanking genomic sequence.