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. 2006 Oct;142(2):441–457. doi: 10.1104/pp.106.086652

Figure 1.

Figure 1.

Isopentenyl diphosphate synthesis via the MEP pathway. Intermediates involved in the biosynthesis are as follows: 1, pyruvate; 2, d-glyceraldehyde 3-phosphate; 3, DXP; 4, MEP; 5, 4-diphosphocytidyl-2C-methyl-d-erythritol; 6, 2-phospho-4-(cytidine 5′-diphospho)-2C-methyl-d-erythritol; 7, 2C-methyl-d-erythritol 2,4-cyclodiphosphate; 8, (E)-4-hydroxy-3-methylbut-2-enyl diphosphate; 9, isopentenyl diphosphate; 10, dimethylallyl diphosphate; 11, DX; and 12, ME. Genes encoding the enzymes of the pathway are as follows: dxs, 1-deoxy-d-xylulose 5-phosphate synthase; dxr, 1-deoxy-d-xylulose 5-phosphate reductoisomerase; ygbP, 4-diphosphocytidyl-2C-methyl-d-erythritol synthase; ychB, 2-phospho-4-(cytidine 5′-diphospho)-2C-methyl-d-erythritol kinase; ygbB, 2C-methyl-d-erythritol 2,4-cyclodiphosphate synthase; gcpE, (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase; lytB, (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase; and idi, isopentenyl diphosphate isomerase.