Table 1.
Effect of ATRA and IL-2 treatment on the number of white blood cells
Parameters | Day 0 Before treatment | Day 7 End of ATRA treatment | Day 14 Before start of IL-2 | Day 28 Two weeks of IL-2 | Day 42 Four weeks of IL-2 |
---|---|---|---|---|---|
WBC (× 106/ml) | 6.22 ± 1.55 | 5.41 ± 1.53 p=0.07 | 6.71 ± 1.92 p=0.31 | 15.75 ± 6.32 p=0.01 | 10.01 ± 3.07 p=0.07 |
Neutrophils (× 106/ml) | 3.99 ± 1.18 | 3.66 ± 1.49 p=0.14 | 4.50 ± 1.60 p=0.18 | 5.51 ± 2.64 p=0.02 | 3.06 ± 1.47 p=0.26 |
Lymphocytes (× 106/ml) | 1.62 ± 0.52 | 1.47 ± 0.29 p=0.15 | 1.53 ± 0.68 p=0.85 | 4.40 ± 1.73 p=0.005 | 3.50 ± 1.40 p=0.001 |
Monocytes (× 106/ml) | 0.58 ± 0.19 | 0.40 ± 0.15 p=0.04 | 0.53 ± 0.17 p=0.23 | 0.66 ± 0.52 p=0.73 | 0.57 ± 0.22 p=0.71 |
Eighteen patients were evaluated. Mean ± st. deviation are shown. P values were calculated using 2-sided Student’s t test. Each time point was compared with pre-treatment level (day 0).