Table 3.

Multipoint LOD score and chromosomal location in the Original, Follow-up and Combined samples are shown.

A Model One LOD scores.
Chromosome Location	Original Sample			Follow-up Sample			Combined Sample
	Distance * (cM)	LOD	p-value	Distance * (cM)	LOD	p-value	Distance * (cM)	LOD	p-value
2q33	200	1.37	0.006	210	0.17	0.2	200	1.37	0.006
4p16	2	2.19	0.0007	0	0	0.5	0	1.94	0.0014
5q31-32	147	1.23	0.009	160	0.15	0.2	142	0.98	0.02
6p22.3	34	1.13	0.011	34	0.01	0.4	34	1.14	0.011
6q23-24	149	2.75	0.0002	142	1.87	0.002	149	4.05	0.00001
18q22	89	1.23	0.009	75	0.79	0.03	89	1.78	0.002
B Model Two LOD scores.
2q33	200	1.56	0.004	210	0.21	0.2	200	1.62	0.003
4p16	2	2.15	0.0008	0	0	0.5	0	1.9	0.002
5q31-32	147	1.27	0.008	160	0.12	0.2	147	0.98	0.02
6p22.3	34	0.88	0.02	34	0.01	0.4	34	0.95	0.02
6q23-24	148	3.5	0.00003	142	2.27	0.0006	149	4.94	<10-6
18q22	89	0.96	0.02	75	0.79	0.02	89	1.55	0.004

A. Model One was used to adjust age at onset and age at onset was adjusted by HD repeats only; B. Model Two was used to adjust age at onset, and age at onset was adjusted by HD repeat, normal repeat and their interaction.

* The genetic distances are as indicated by the Marshfield linkage map [26]