Table 3.
Mouse number | Body weight (g) | Heart | Lungs | Liver | Kidney | Thymus | Spleen | Skin site collected |
---|---|---|---|---|---|---|---|---|
Group 1: Vehicle | ||||||||
98-0030 | 21.9 | 0.1504 | 0.1512 | 1.1281 | 0.3507 | 0.0707 | 0.0880 | No |
98-0031 | 20.6 | 0.1365 | 0.1574 | 1.1912 | 0.2920 | 0.0718 | 0.0621 | No |
98-0032 | 21.8 | 0.1547 | 0.1862 | 1.1875 | 0.3477 | 0.0541 | 0.1002 | No |
Mean | 21.4 | 0.1472 | 0.1649 | 1.1689 | 0.3301 | 0.0655 | 0.0834 | |
S.D. | 0.7 | 0.0095 | 0.0187 | 0.0354 | 0.0331 | 0.0099 | 0.0195 | |
Group 2: 0.012 mg/(kg day) | ||||||||
98-0033 | 20.3 | 0.1279 | 0.1507 | 1.2729 | 0.3045 | 0.0743 | 0.0782 | No |
98-0034 | 22.0 | 0.1380 | 0.1762 | 1.2064 | 0.3573 | 0.0627 | 0.0760 | No |
98-0035 | 21.2 | 0.1442 | 0.1662 | 1.1755 | 0.3583 | 0.0892 | 0.0992 | No |
Mean | 21.2 | 0.1367 | 0.1644 | 1.2183 | 0.3400 | 0.0754 | 0.0845 | |
S.D. | 0.9 | 0.0082 | 0.0128 | 0.0498 | 0.0308 | 0.0133 | 0.0128 | |
Group 3: 1.2 mg/(kg day) | ||||||||
98-0036 | 24.5 | 0.1449 | 0.2062 | 1.4937 | 0.3988 | 0.0605 | 0.1027 | No |
98-0037 | 20.9 | 0.1204 | 0.1792 | 1.0268 | 0.2862 | 0.0640 | 0.0889 | No |
98-0038 | 22.9 | 0.1443 | 0.1961 | 1.3002 | 0.3651 | 0.0730 | 0.0946 | No |
Mean | 22.8 | 0.1365 | 0.1938 | 1.2736 | 0.3500 | 0.0658 | 0.0954 | |
S.D. | 1.8 | 0.0140 | 0.0136 | 0.2346 | 0.0578 | 0.0064 | 0.0069 | |
Group 4: 120 mg/(kg day) | ||||||||
98-0039 | 21.4 | 0.1910 | 0.1849 | 1.4325 | 0.4327 | 0.0604 | 0.0786 | 1, 2, 4, 6 |
98-0040 | 25.6 | 0.1529 | 0.2036 | 1.7887 | 0.4467 | 0.0567 | 0.1704 | 0, 1, 3, 5 |
98-0041 | 25.0 | 0.1182 | 0.1522 | 1.3370 | 0.3949 | 0.0455 | 0.1402 | 0, 3, 4, 6 |
Mean | 24.0 | 0.1540 | 0.1802 | 1.5194 | 0.4248 | 0.0542 | 0.1297 | |
S.D. | 2.3 | 0.0364 | 0.0260 | 0.2381 | 0.0268 | 0.0078 | 0.0468 | |
Group 5: 60 mg/(kg day) | ||||||||
98-0042 | 19.8 | 0.1275 | 0.1377 | 1.0620 | 0.2581 | 0.0930 | 0.0701 | 6 |
98-0043 | 23.3 | 0.1503 | 0.2056 | 1.3253 | 0.3559 | 0.0703 | 0.0610 | 1, 3 |
98-0044 | 21.9 | 0.1327 | 0.2008 | 1.2690 | 0.3515 | 0.0616 | 0.0856 | 1, 5 |
Mean | 21.7 | 0.1368 | 0.1814 | 1.2188 | 0.3218 | 0.0750 | 0.0722 | |
S.D. | 1.8 | 0.0119 | 0.379 | 0.1387 | 0.0552 | 0.0162 | 0.0124 |