Table 2.
Biodistribution of 30 μg 111 In MN14 at five different times
24 h
|
36 h
|
48 h
|
60 h
|
72 h
|
||||||
---|---|---|---|---|---|---|---|---|---|---|
Organ | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD |
(A) %ID/g | ||||||||||
Liver | 12.24 | 2.25 | 14.44 | 1.08 | 16.21 | 1.44 | 11.39 | 1.10 | 14.35 | 0.75 |
Heart | 1.32 | 0.07 | 1.08 | 0.32 | 0.99 | 0.16 | 0.68 | 0.15 | 0.74 | 0.16 |
Kidney | 11.53 | 2.16 | 12.36 | 1.64 | 11.72 | 0.39 | 11.55 | 1.16 | 11.51 | 0.81 |
Lung | 2.02 | 0.27 | 1.90 | 0.31 | 1.79 | 0.33 | 1.31 | 0.13 | 1.26 | 0.38 |
Spleen | 5.00 | 0.84 | 5.08 | 0.33 | 6.90 | 0.72 | 3.83 | 0.25 | 4.50 | 0.55 |
Muscle | 0.56 | 0.08 | 0.45 | 0.10 | 0.46 | 0.08 | 0.35 | 0.06 | 0.45 | 0.05 |
Tumor | 7.68 | 1.79 | 8.87 | 0.63 | 8.59 | 3.51 | 8.69 | 0.97 | 8.22 | 1.42 |
Blood | 3.54 | 0.25 | 2.67 | 0.49 | 2.24 | 0.29 | 1.11 | 0.29 | 0.60 | 0.19 |
(B) %ID/organ | ||||||||||
Stomach | 0.36 | 0.04 | 0.32 | 0.10 | 0.39 | 0.08 | 0.29 | 0.01 | 0.29 | 0.02 |
Sm. int. | 1.59 | 0.22 | 1.60 | 0.27 | 1.77 | 0.07 | 1.28 | 0.14 | 1.48 | 0.06 |
Lg. int. | 0.68 | 0.07 | 0.76 | 0.08 | 0.87 | 0.09 | 0.62 | 0.07 | 0.75 | 0.12 |
Whole body | 70.2 | 3.5 | 66.9 | 2.8 | 63.1 | 2.4 | 58.7 | 1.0 | 56.6 | 1.1 |
Mean of %ID/g (A) or %ID/ organ (B) with standard deviation (SD); n=4
Sm. int. small intestine, Lg. int. large intestine