Table 3.
Biodistribution of 99m Tc-cMORF in tumor-bearing mice receiving 30 μg MN14-MORF followed 48 h later by one to four injections of 0.15 μg of 99m Tc-cMORF separated by 1 h, with sacrifice at 3 h after the last injection
| 1 injection
|
2 injections
|
3 injections
|
4 injections
|
|||||
|---|---|---|---|---|---|---|---|---|
| Organ | Mean | SD | Mean | SD | Mean | SD | Mean | SD |
| (A) %ID/g | ||||||||
| Liver | 0.86 | 0.21 | 0.71 | 0.08 | 0.50 | 0.13 | 0.48 | 0.02 |
| Heart | 0.42 | 0.14 | 0.40 | 0.10 | 0.26 | 0.08 | 0.25 | 0.06 |
| Kidney | 4.57 | 1.56 | 4.18 | 0.69 | 3.19 | 0.28 | 2.59 | 0.41 |
| Lung | 0.68 | 0.19 | 0.66 | 0.13 | 0.37 | 0.07 | 0.38 | 0.02 |
| Spleen | 0.39 | 0.08 | 0.34 | 0.08 | 0.22 | 0.02 | 0.22 | 0.02 |
| Muscle | 0.22 | 0.03 | 0.25 | 0.12 | 0.12 | 0.03 | 0.13 | 0.03 |
| Tumor | 4.39 | 0.74 | 4.42 | 0.52 | 3.80 | 0.36 | 2.95 | 0.31 |
| Fibula bone | 0.36 | 0.04 | 0.32 | 0.07 | 0.23 | 0.03 | 0.24 | 0.03 |
| Blood | 1.73 | 0.30 | 1.50 | 0.25 | 0.87 | 0.17 | 0.75 | 0.05 |
| (B) %ID/organ | ||||||||
| Stomach | 0.13 | 0.02 | 0.23 | 0.17 | 0.07 | 0.01 | 0.09 | 0.02 |
| Sm. int. | 0.42 | 0.08 | 0.46 | 0.16 | 0.28 | 0.08 | 0.23 | 0.05 |
| Lg. int. | 2.23 | 0.66 | 2.17 | 0.12 | 1.54 | 0.39 | 2.08 | 0.55 |
Mean of %ID/g (A) or %ID/organ (B) with standard deviation (SD); n=4
Sm. int. small intestine, Lg. int. large intestine