Table 4.
Biodistribution of 99m Tc-cMORF in animals receiving 30 μg MN14-MORF 2, 3, or 4 days earlier, with sacrifice 3 h post injection of 0.30 μg of labeled cMORF
| 2-day interval
|
3-day interval
|
4-day interval
|
||||
|---|---|---|---|---|---|---|
| Organ | Mean | SD | Mean | SD | Mean | SD |
| (A) %ID/g | ||||||
| Liver | 0.60 | 0.05 | 0.54 | 0.03 | 0.37 | 0.02 |
| Heart | 0.30 | 0.07 | 0.22 | 0.03 | 0.14 | 0.02 |
| Kidney | 4.96 | 1.39 | 5.28 | 0.35 | 4.87 | 0.86 |
| Lung | 0.74 | 0.16 | 0.41 | 0.07 | 0.37 | 0.09 |
| Spleen | 0.33 | 0.06 | 0.29 | 0.05 | 0.22 | 0.04 |
| Muscle | 0.19 | 0.02 | 0.13 | 0.02 | 0.09 | 0.01 |
| Thyroid | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Tumor | 3.09 | 0.27 | 3.27 | 0.47 | 2.12 | 0.46 |
| Blood | 1.27 | 0.17 | 0.93 | 0.08 | 0.58 | 0.13 |
| (B) %ID/organ | ||||||
| Stomach | 0.27 | 0.05 | 0.30 | 0.07 | 0.27 | 0.03 |
| Sm. int. | 0.40 | 0.12 | 0.49 | 0.12 | 0.32 | 0.04 |
| Lg. int. | 0.41 | 0.15 | 0.44 | 0.04 | 0.36 | 0.04 |
| Whole body | 18.9 | 1.4 | 14.7 | 0.4 | 13.0 | 2.1 |
Mean of %ID/g (A) or %ID/organ (B) with standard deviation (SD); n=4
Sm. int. small intestine, Lg. int. large intestine