Table 5.
Comparison between experimental and theoretical blood levels (%ID/g) in pretargeting with 30 μg MN14-MORF and 0.30 μg labeled cMORF
Blood level of labeled cMORF
|
|||
---|---|---|---|
Pretargeting interval | Blood level of MN14-MORFa | Theoreticalb | Experimental |
2 days | 1.94 | 1.38 | 1.27±0.17 |
3 days | 1.02 | 0.77 | 0.93±0.08 |
4 days | 0.53 | 0.44 | 0.58±0.13 |
Calculated from the antibody blood clearance curve
The theoretical blood level of labeled cMORF (%ID/g)=the blood level of antibody-MORF (%ID/g)×dose of antibody-MORF ÷ MWantibody×gmp×MWcMORF ÷ dose of labeled cMORF+background blood level of free labeled cMORF=the blood level of antibody-MORF (%ID/g)×30 μg÷160,000×0.17×6331÷0.30 μg+0.08. The 0.08 is from reference [18]