Abstract
Interaction between the tricyclic antidepressant desipramine and the antihypertensive agent clonidine has been investigated in five hypertensive patients in a double-blind placebo controlled study. Introduction of the tricyclic antidepressant led to loss of blood pressure control in four of the patients. The average blood pressure rise in the desipramine period compared with the placebo period was 22/15 mm Hg in the lying position and 12/11 mm Hg standing. Thus addition of a tricyclic antidepressant may lead to loss of blood pressure control in a hypertensive patient treated with clonidine.
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Selected References
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- Briant R. H., Reid J. L. Desmethylimipramine and the hypotensive action of clonidine in the rabbit. Br J Pharmacol. 1972 Nov;46(3):563P–564P. [PMC free article] [PubMed] [Google Scholar]
- LEISHMAN A. W., MATTHEWS H. L., SMITH A. J. Anatgonism of guanethidine by imipramine. Lancet. 1963 Jan 12;1(7272):112–112. doi: 10.1016/s0140-6736(63)91123-1. [DOI] [PubMed] [Google Scholar]
- Mitchell J. R., Arias L., Oates J. A. Antagonism of the antihypertensive action of guanethidine sulfate by desipramine hydrochloride. JAMA. 1967 Dec 4;202(10):973–976. [PubMed] [Google Scholar]
- Mitchell J. R., Cavanaugh J. H., Arias L., Oates J. A. Guanethidine and related agents. 3. Antagonism by drugs which inhibit the norepinephrine pump in man. J Clin Invest. 1970 Aug;49(8):1596–1604. doi: 10.1172/JCI106377. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schmitt H., Boissier J. R., Giudicelli J. F., Fichelle J. Cardiovascular effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (ST 155). II. Central sympathetic structures. Eur J Pharmacol. 1968 Mar;2(5):340–346. doi: 10.1016/0014-2999(68)90184-2. [DOI] [PubMed] [Google Scholar]
- Werner U., Starke K., Schümann H. J. Actions of clonidine and 2-(2-methyl-6-ethyl-cyclohexylamino)-2-oxazoline on postganglionic autonomic nerves. Arch Int Pharmacodyn Ther. 1972 Feb;195(2):282–290. [PubMed] [Google Scholar]
- Zaimis E., Hanington E. A possible pharmacological approach to migraine. Lancet. 1969 Aug 9;2(7615):298–300. doi: 10.1016/s0140-6736(69)90058-0. [DOI] [PubMed] [Google Scholar]