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STZ treatment damages DNA in PARP +/+, PARP +/−, and PARP −/− mice. PUNT+ labeling of DNA strand breaks in mouse pancreatic islet cells shows that i.p. injection of 200 mg/kg STZ elicits comparable DNA damage 5 days later in PARP +/+, PARP +/−, and PARP −/− mice. Baseline pancreatic islet cell DNA damage is higher in PARP +/− and PARP −/− mice than in PARP +/+ mice. These results are samples of at least five independent replications.
