Figure 1.

Comparison of ORFV2-VEGF with other members of the VEGF family of growth factors. The deduced amino acid sequence of ORFV2-VEGF was aligned with the sequences of VEGF₁₂₁ (10), VEGF₁₆₅ (49), PlGF (12), VEGF-B₁₆₇ (13), and truncated sequences of VEGF-C (50) and VEGF-D (15). The residues that show identity with ORFV2-VEGF are boxed. The conserved cysteine residues of the cystine knot motif are indicated with an asterisk. The signal sequence, as determined by N-terminal sequencing, is indicated by the line above the sequence. The potential sites of N-and O-linked glycosylation are indicated by a bracket and dashed line, respectively. The VEGF homology domain is indicated by arrows.