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. 1999 Mar 16;96(6):3081–3086. doi: 10.1073/pnas.96.6.3081

Figure 6.

Figure 6

Effect of EGF-R tyrosine kinase inhibitor (BIBX1522) on production of goblet cells (expressed as % stained area of airway epithelium occupied by AB–PAS-positive stained cells). (A) Stimulation with TNFα (200 ng, 100 μl). Tracheal instillation of TNFα, followed by the EGF-R ligand TGFα, increased goblet-cell production significantly (n = 5; ∗, P < 0.0001), an effect that was inhibited by pretreatment with BIBX1522 (3–30 mg/kg, i.p.) dose-dependently (n = 5; P compared with TNFα followed by TGFα: †, P = 0.003; ††, P < 0.0001). (B) Ovalbumin sensitization. Animals given ovalbumin intraperitoneally (i.p.) only showed little AB–PAS-positive staining in bronchial epithelium. Animals first sensitized with ovalbumin (OVA) i.p., followed by three intratracheal (i.t.) instillations of OVA, showed a marked increase in AB–PAS-positive staining (n = 5; ∗, P < 0.0001). Pretreatment with BIBX1522 (10 mg/kg, i.p.) inhibited OVA-induced production of goblet cells (n = 5; ††, P < 0.0001).