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Degradation of CFTR cytosolic domains is unaffected by p97. Purified NBD1 (A) or NBD1-R (C) was added directly to degradation reactions containing mock-depleted RRL or p97-depleted RRL with or without added recombinant p97 as indicated. Also shown are degradation rates in ATP-depleted RRL (−ATP) and in the presence of MG132. (B, D) Initial degradation rates were calculated from panels A and C. Location of domain in the CFTR polypeptide is indicated in Figure 1A.
