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Degradation of CFTR TMD1. (A) TMD1 topology showing location of methionines and length of cytosolic and lumenal loops. Carbonate extraction of in vitro-expressed TMD1. (B) TMD1 degradation was assayed in the presence and absence of p97 as in Figure 4. Also shown are effects of MG132 and ATP depletion. (C) Initial rates of TMD1 degradation in mock RRL, p97-depleted RRL and after p97 supplementation.
