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Effects of the hMLH 1 exon 17 mutations on ESE sequences identified by the different algorithms. The complete sequence of exon 17 is shown (exonic sequence in capital bold). Numbering is relative to the nucleotide position in the ORF. The four exon 17 mutations are shown, wild type sequence underlined. The consequences of the four mutations on the predicted motif scores identified by ESEfinder, RescueESE and PESX are shown below.
