Figure 3.

Synergistic effect on CCL18 secretion by monocytes upon stimulation with IL-4/IL-13 in combination with IL-10. MACS isolated monocytes were cultured for 6 days and stimulated on day 1 with IL-4 (500 U/ml), IL-13 (20 ng/ml), IL-10 (20 ng/ml) or a combination of the cytokines. The bars represent the mean (± SEM) CCL18 (pg/ml) of 6 individual experiments. In all experiments, a direct comparison was made with with unstimulated cells. ND = not detectable. * represents a p-value of <0,05 (Wilcoxon Signed Rank test)