Table 1.
Semiquantitative evaluation of the IGF-II production (increase in the concentration of IGF-II in the medium) of some human cancer cell lines in tissue culture
| Cancer cell line | Increase by 2–12 ng/ml | Increase by <2 ng/ml | No increase |
|---|---|---|---|
| Breast | MDA-MB-468 | ZR-75-1 | MCF-7-M-III† MDA-MB-231 MCF-7-LCC1† T47D |
| Prostatic | PC-3 | DU-145 | LNCaP |
| Lung | |||
| SCLC | H-69 | H-510 | H-345† |
| non-SCLC | H-23 | H-157† | |
| Pancreatic | MiaPaCa-2 SW-1990 | Capan-2 | Panc-1† |
| Ovarian | OV-1063 SKOV-3 | ||
| Colorectal | LoVo | HT-29 | |
| Choriocarcinoma | JAR† | ||
| Osteosarcoma | MG-63 | ||
| Glioma | U-373-MG | ||
| Endometrial | HEC-1A | ||
| Total | 6 | 7 | 13 |
The cell lines were grouped according to the increase in the amount of IGF-II in the medium. The incubation time varied from 2 to 5 days depending on the rate of proliferation of the cells.
†
Cell lines showing a decrease in IGF-II content in the medium.
SCLC, small-cell lung carcinoma; non-SCLC, non-small-cell lung carcinoma.