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Primary screening of monoclonal antibodies for reactivity with different mutant TTR molecules
| TTR | mAb 47 | mAb 11 | mAb 14 | mAb 17 | mAb 15 |
|---|---|---|---|---|---|
| Wild type | + | − | + | + | + |
| V30M | + | − | ND | ND | + |
| s53-55 | + | + | + | + | + |
| del53-55 | + | − | + | + | + |
| pINTR-RM (wild type) | − | − | − | − | + |
| pINTR-10 (C10S) | + | − | − | − | + |
| pINTR-30 (V30M) | + | − | − | − | + |
| pINTR-55 (L55P) | + | − | − | − | + |
| pINTR-119 (T119M) | + | − | − | − | + |
The antibodies were tested with a direct ELISA. ND, not determined, plasmid designation according to Materials and Methods.
