Figure 3.

Alignment of the deduced amino acid sequence of prostase with the serine proteases EMSP1, SCCE, protease M, hK1, hK2, hK3, rat KLK8, mouse KLK1, and trypsin. GenBank accession numbers are listed. Amino acid sequence identity (black) or similarity (gray) between prostase and at least one other protein is shaded. Dashes represent gaps to bring the sequences to better alignment. The serine protease catalytic triad of histidine, aspartic acid, and serine are boxed vertically and denoted with an ∗. The 29 invariant serine protease residues are indicated by ●. The Asn residue conferring trypsin cleavage specificity is indicated by a cross. The hatched horizontal bar indicates the kallikrein loop sequence.