Figure 2.

Biodistribution of a nonspecific (A) and a specific (B) mAb in LS174T tumor-bearing mice at 4 hr postinjection. The data, expressed as a percentage of injected dose per g of tissue, are averaged over five animals and represent the sum of interstitial and vascular uptake (bars = SEM). There is no significant effect of MABP modulation on nonspecific mAb uptake (A). A net increase in total tumor uptake of CC49 specific antibody resulted from both continuous (P < 0.03, ANOVA) and cyclic (P < 0.04, ANOVA) infusion of AGII (B). Modulation of MABP also induced significant increases in lung and kidney uptake.