Table 1.
Statistical analysis of the slopes and intercepts of the uptake kinetics of the nonspecific (HYNIC) and the specific CC49 antibodies
| Group | Slope × 104 (mean ± SD)
|
Intercept × 102 (mean ± SD)
|
||
|---|---|---|---|---|
| Nonspecific mAb | Specific mAb | Nonspecific mAb | Specific mAb | |
| Control | 3.3 ± 0.2 | 10 ± 1 | 4.0 ± 0.7 | 6.7 ± 3.9 |
| Continuous | 2.8 ± 0.4 | 10 ± 1 | 5.5 ± 0.9 | 8.2 ± 9.9 |
| Cycling | 2.4 ± 0.6 | 20 ± 10 | 3.5 ± 0.3 | 6.7 ± 3.5 |
The data, obtained by a linear fit of the gamma camera counts vs. time as shown in Fig. 3, are averaged over five animals and represent the interstitial uptake rate (slope) and vascular space (intercept). There is no significant effect of chronic increase or periodic modulation of MABP on the nonspecific mAb interstitial uptake rate. The data indicate that periodic modulation of MABP induced a 2-fold increase of the average value of specific antibody interstitial uptake rate compared with the control.