Table 2.

Concentrations of the cerebrospinal fluid (CSF) markers in CJD

CSF marker	median (range)	reference cut-off*
NSE (n = 57)	70 (9–200) ng/ml	12.5 ng/ml
tau (n = 56)	6764 (3772–27770) pg/ml	195 pg/ml
phosphorylated tau (n = 33)	55 (18.4–138) pg/ml	61 pg/ml
14-3-3 (n = 51)	984 (410–5387) ng/ml	200 ng/ml
S 100b (n = 54)	8 (1.4–39.2) ng/ml	2 ng/ml
PrP (n = 45)	15.7 (1–40.9) ng/100ml	22 ng/100ml
Aβ1–42	467 (143–959) pg/ml	849 pg/ml

*: data were taken according to the manufacturers instruction in cases where commercially developed kits are available, otherwise calculated based on results from non-neurological controls from our study (14-3-3 and PrP)