Table 6.

Synopsis of the degree of pathological changes and levels of various brain-derived proteins in the CSF

	Spongiform change/neuronal loss/gliosis *
	Cortical Regions	Subcortical Regions		Cerebellum
		basal ganglia	thalamus
NSE	↔/↔/↔	↔/↑/↑	↑/↔/↔	↔/↑/↑
tau	↓/↓/↔	↔/↔/↑	↔/↓/↔	↑/↔/↑
phosphorylated tau	↓/↓/↓	↔/↔/↔	↑/↓/↓	↑/↔/↔
14-3-3	↓/↔/↔	↔/↔/↔	↑/↓/↔	↔/↔/↔
S 100b	↓/↓/↓	↔/↔/↑	↑/↓/↓	↔/↔/↑
PrP	↓/↓/↓	↔/↓/↓	↔/↔/↓	↑/↓/↔
Aβ 1–42	↓/↓**/↓	↓/↓/↓	↔/↓/↓	↑/↔/↔

*: within the cells in the table the first arrow shows spongiform change, the second shows nerve cell loss and the third gliosis; only the strongest neuropathological changes among the different regions are shown in the table

**: strong correlation

↔ correlation coefficient from -0.2 to +0.2: no correlation

↑ correlation coefficient from +0.2 to +0.6: weak correlation

↓ correlation coefficient from -0.2 to -0.6: weak correlation.