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. Author manuscript; available in PMC: 2006 Oct 5.
Published in final edited form as: Chromosoma. 2004 May 25;112(8):398–409. doi: 10.1007/s00412-004-0285-5

Fig. 5.

Fig. 5

Differentiation of UR61 cells upregulates nuclear and cytoplasmic SMN (survival of motor neurons protein product). Immunoblot analysis of proteins extracted from nuclear and cytoplasmic fractions of UR61 cells using a mouse monoclonal anti-SMN antibody. Purity of subcellular fractions was checked using antibodies against tyrosine hydroxylase (TH, cytoplasm) and fibrillarin (nucleus). Dexamethasone (Dex)-induced differentiation increases the expression level of SMN in both nuclear and cytoplasmic fractions. Dexamethasone also induces a dramatic increase in the expression of tyrosine hydroxylase in cytoplasmic extracts