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(a) Diagram showing timescale of treatments, (b and c) Effects of the MR antagonist SPIR and GR antagonist MIFE on proliferation as demonstrated by (b) BrdU and (c) Ki-67 cell counts. Adrenalectomy significantly stimulated proliferation (§P < 0.001), and corticosterone replacement with a 30% corticosterone pellet restored proliferation to basal levels. SPIR significantly enhanced proliferation (†P < 0.007), but there was no observed effect of MIFE. ‡P < 0.043.
