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. 2006 Oct 7;333(7571):726. doi: 10.1136/bmj.38947.697558.AE

Table 3.

Number of person years' treatment needed to produce one excess case of serious upper gastrointestinal bleeding. Estimates are based on data for people aged 50 or above

Exposure Total drug exposure in background population (person years) NNTH: person years−1 (95% CI)
Aspirin alone 40 599 1040 (725 to 1641)
Clopidogrel alone 2 391 8800 (NNTH 723 to ∞; NNTB 1832 to ∞)
VKA alone 13 205 985 (550 to 2372)
Dipyridamole alone 8 007 873 (445 to 2557)
Aspirin and clopidogrel 739 124 (54 to 312)
Aspirin and VKA 1 213 184 (93 to 407)
Dipyridamole and aspirin 7 713 595 (348 to 1201)

NNTB=number needed to treat for one patient to benefit; NNTH=number needed to treat for one patient to be harmed; VKA=vitamin K antagonist.