Table 3.
Number of person years' treatment needed to produce one excess case of serious upper gastrointestinal bleeding. Estimates are based on data for people aged 50 or above
| Exposure | Total drug exposure in background population (person years) | NNTH: person years−1 (95% CI) |
|---|---|---|
| Aspirin alone | 40 599 | 1040 (725 to 1641) |
| Clopidogrel alone | 2 391 | 8800 (NNTH 723 to ∞; NNTB 1832 to ∞) |
| VKA alone | 13 205 | 985 (550 to 2372) |
| Dipyridamole alone | 8 007 | 873 (445 to 2557) |
| Aspirin and clopidogrel | 739 | 124 (54 to 312) |
| Aspirin and VKA | 1 213 | 184 (93 to 407) |
| Dipyridamole and aspirin | 7 713 | 595 (348 to 1201) |
NNTB=number needed to treat for one patient to benefit; NNTH=number needed to treat for one patient to be harmed; VKA=vitamin K antagonist.