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. Author manuscript; available in PMC: 2006 Oct 6.
Published in final edited form as: Cancer Res. 2005 Jul 15;65(14):6380–6387. doi: 10.1158/0008-5472.CAN-05-0575

Table 1.

IC50 and IC80 for DBPT in human colorectal cancer cell lines and NHFBs

DBPT concentration
Cell line P-gp status IC50(μM) IC80(μM)
DLD-1 +++ 1.6 ± 0.3 2.7 ± 0.3
HCT116 (p53+) ± 4.9 ± 0.3 ND
HCT116 (p53−) ± 5.9 ± 0.3 ND
NHFB ND 22.9 ± 7.2 ND

Cells were grown in the presence of DBPT for 72 h, and cell viability was determined by XTT assay. P-gp levels were evaluated by western blot analysis. p53+, wild type; p53−, p53 deficient; ND, not determined. Each value in the DBPT columns represents the mean ± SD of three independent experiments.