Table 1.
DBPT concentration |
|||
---|---|---|---|
Cell line | P-gp status | IC50(μM) | IC80(μM) |
DLD-1 | +++ | 1.6 ± 0.3 | 2.7 ± 0.3 |
HCT116 (p53+) | ± | 4.9 ± 0.3 | ND |
HCT116 (p53−) | ± | 5.9 ± 0.3 | ND |
NHFB | ND | 22.9 ± 7.2 | ND |
Cells were grown in the presence of DBPT for 72 h, and cell viability was determined by XTT assay. P-gp levels were evaluated by western blot analysis. p53+, wild type; p53−, p53 deficient; ND, not determined. Each value in the DBPT columns represents the mean ± SD of three independent experiments.