Figure 2.

Differential modulation of glycine receptor subtypes by Zn²⁺. (A) With 1 μM strychnine, the fast component of the glycine response was blocked (traces a and c), the slow component in 1 μM Zn²⁺ were shown as trace b, and in 100 μM Zn²⁺ were shown as trace d. (B) In the presence of 500 μM DCKA, the slow component was blocked (trace a and c), and trace b and d illustrate the fast component in 1 μM Zn²⁺ and 100 μM Zn²⁺, respectively. In each case, trace a and b were from the same cell, as were trace c and d. All current responses were recorded under voltage-clamp conditions at a holding potential of 0 mV.