Table 1.

Comparison of serum levels (median, minimal, and maximal values) of VEGF, bFGF, syndecan 1, and endostatin in the healthy control group and in 52 untreated B-CLL patients.

		B-CLL patients					P
Cytokine	Controls	All	LDT < 12	LDT ≥ 12	Stable	Progressive
		patients	months	months	Disease	Disease
	N = 12	N = 52	N = 10	N = 42	N = 30	N = 22
	1	2	3	4	5	6	1	2	3
							versus	versus	versus
							2	4	6
VEGF	456.2	326.5	247.43	351.9	326.5	322.3	NS	NS	NS
pg/mL	(122.4−1029.6)	(84.5−1547.8)	(89.2−762.9)	(84.5−1547.8)	(84.5−833.4)	(89.2−1547.8)
bFGF	0.2	18.4	11.64	20.9	16.4	20.9	.00001	NS	.03
pg/mL	(0.0−2.4)	(0.0−529.5)	(0.0−153.2)	(0.0−529.5)	(3.3−120.7)	(0.0−529.5)
sCD138	36.7	149.0	54.2	178.8	187.9	65.1	.0002	.03	.03
ng/mL	(17.4−135.8)	(13.2−257.1)	(13.2−201.2)	(18.4−257.1)	(27.3−257.1)	(13.2−257.1)
Endostatin	5.9	8.12	8.38	8.12	7.56	9.34	NS	NS	NS
pg/mL	(2.1−12.0)	(2.3−20.6)	(3.8−9.9)	(2.3−20.6)	(2.3−18.5)	(3.8−20.6)