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. 2006 Oct 10;103(42):15422–15427. doi: 10.1073/pnas.0607058103

Fig. 6.

Fig. 6.

Structure of SP4160 (green sticks) bound to IL-2. Red and blue represent oxygen and nitrogen atoms, respectively. The structure of SP4206 from its x-ray coordinates (yellow sticks) is overlaid onto SP4160. Note the close superposition except in the region of the benzyl acylamide in SP4160 versus the carboxyfuran in SP4206 on the left. Also, note the absence of the binding pocket in IL-2 for the carboxyfuran moiety of SP4206 seen in Fig. 3B. The positions of hot-spot residues (F42, Y45, and E65) are labeled.